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Complex mode of action of deprenyl in protection against MPTP-Parkinsonism in mice

✍ Scribed by Sziráki, I.; Kardos, V.; Patthy, M.; Pátfalusi, M.; Gaál, J.; Solti, M.; Kollár, E.

Book ID
122623667
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
129 KB
Volume
21
Category
Article
ISSN
0197-0186

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Deprenyl slows the progression of disabling symptoms in Parkinson's disease (PD) by an unknown mechanism. It can block the action of MPTP on substantia nigra compacta (SNc) neurons by inhibiting monoamine oxidase B necessary to mediate the conversion of MPTP to MPP +, its active metabolite, in astro