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The possible mechanisms of action of (-)deprenyl in Parkinson's disease

✍ Scribed by J. Knoll


Publisher
Springer
Year
1978
Tongue
English
Weight
983 KB
Volume
43
Category
Article
ISSN
1435-1463

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Deprenyl slows the progression of disabling symptoms in Parkinson's disease (PD) by an unknown mechanism. It can block the action of MPTP on substantia nigra compacta (SNc) neurons by inhibiting monoamine oxidase B necessary to mediate the conversion of MPTP to MPP +, its active metabolite, in astro