Possible mechanism for the generation of the HIV-1-resistant form of the CCR5 Δ32 mutant chemokine receptor
✍ Scribed by Daryl Faulds; Richard Horuk
- Book ID
- 114320288
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 225 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0960-9822
No coin nor oath required. For personal study only.
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Entry of HIV-1 into a cell happens only after viral envelope glycoproteins have bound to CD4 and a chemokine receptor. Generally, macrophage-tropic strains use CCR5, and T cell-line-tropic strains use CXCR4 as coreceptors for virus entry. Dual-tropic viruses can use both CCR5 and CXCR4. About 1% of
The 32 nucleotide deletion in the CCR-5 chemokine receptor gene referred to as ⌬ccr-5 has been shown to confer resistance to HIV-1. Using PCR, 1,105 human subjects and 33 common chimpanzees were genotyped attributing them to one of the three possible genotypes: wild-type homozygote (w/w); ⌬ccr-5 hom