Persistence of dual-tropic HIV-1 in an i
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Paul R Gorry; Chengsheng Zhang; Sam Wu; Kevin Kunstman; Elizabeth Trachtenberg;
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Article
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2002
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The Lancet
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English
⚖ 83 KB
Entry of HIV-1 into a cell happens only after viral envelope glycoproteins have bound to CD4 and a chemokine receptor. Generally, macrophage-tropic strains use CCR5, and T cell-line-tropic strains use CXCR4 as coreceptors for virus entry. Dual-tropic viruses can use both CCR5 and CXCR4. About 1% of