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Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5Δ32 allele

✍ Scribed by Paul R Gorry; Chengsheng Zhang; Sam Wu; Kevin Kunstman; Elizabeth Trachtenberg; John Phair; Steven Wolinsky; Dana Gabuzda


Book ID
117280742
Publisher
The Lancet
Year
2002
Tongue
English
Weight
83 KB
Volume
359
Category
Article
ISSN
0140-6736

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Persistence of dual-tropic HIV-1 in an i
✍ Paul R Gorry; Chengsheng Zhang; Sam Wu; Kevin Kunstman; Elizabeth Trachtenberg; 📂 Article 📅 2002 🏛 The Lancet 🌐 English ⚖ 83 KB

Entry of HIV-1 into a cell happens only after viral envelope glycoproteins have bound to CD4 and a chemokine receptor. Generally, macrophage-tropic strains use CCR5, and T cell-line-tropic strains use CXCR4 as coreceptors for virus entry. Dual-tropic viruses can use both CCR5 and CXCR4. About 1% of