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HIV-1 infection in an individual homozygous for the CCR5 deletion allele

โœ Scribed by Biti, Robyn; Ffrench, Rosemary; Young, Judy; Bennetts, Bruce; Stewart, Graeme; Liang, Tong

Book ID
109927671
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
226 KB
Volume
3
Category
Article
ISSN
1078-8956

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Entry of HIV-1 into a cell happens only after viral envelope glycoproteins have bound to CD4 and a chemokine receptor. Generally, macrophage-tropic strains use CCR5, and T cell-line-tropic strains use CXCR4 as coreceptors for virus entry. Dual-tropic viruses can use both CCR5 and CXCR4. About 1% of