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HIV-1 infection in an individual homozygous for CCR5▵32

✍ Scribed by loannis Theodorou; Laurence Meyer; Magdalena Magierowska; Christine Katlama; Christine Rouzioux

Book ID
119503479
Publisher
The Lancet
Year
1997
Tongue
English
Weight
42 KB
Volume
349
Category
Article
ISSN
0140-6736

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Entry of HIV-1 into a cell happens only after viral envelope glycoproteins have bound to CD4 and a chemokine receptor. Generally, macrophage-tropic strains use CCR5, and T cell-line-tropic strains use CXCR4 as coreceptors for virus entry. Dual-tropic viruses can use both CCR5 and CXCR4. About 1% of