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Possible involvement of cyclic GMP in growth control of cultured mouse cells

✍ Scribed by SEIFERT, W. E.; RUDLAND, P. S.

Book ID
109689594
Publisher
Nature Publishing Group
Year
1974
Tongue
English
Weight
404 KB
Volume
248
Category
Article
ISSN
0028-0836

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## Abstract Theophylline, a cyclic nucleotide phosphodiesterase inhibitor, increases the rate of tyrosine aminotransferase (TAT) degradation in rat hepatoma tissue culture (HTC) cells. Theophylline (0.1–10 mM) causes a two‐ to five‐fold increase in intracellular cAMP concentration but a 30–60% decr