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Positron emission tomography study of pindolol occupancy of 5-HT1A receptors in humans: preliminary analyses

✍ Scribed by Diana Martinez; Osama Mawlawi; Dah-Ren Hwang; Justine Kent; Norman Simpson; Ramin V Parsey; Tomoki Hashimoto; Mark Slifstein; Yiyun Huang; Ronald Van Heertum; Anissa Abi-Dargham; Stephen Caltabiano; Andrea Malizia; Hugh Cowley; J.John Mann; Marc Laruelle

Book ID
117687620
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
229 KB
Volume
27
Category
Article
ISSN
0969-8051

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Pindolol occupancy of 5-HT1A receptors m
Pindolol occupancy of 5-HT1A receptors measured in vivo using small animal positron emission tomography with carbon-11 labeled WAY 100635
✍ Ella Hirani; Jolanta Opacka-Juffry; Roger Gunn; Imtiaz Khan; Trevor Sharp; Susan πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 362 KB πŸ‘ 1 views

Positron emission tomography (PET), following an intravenous injection of [carbonyl-(11)C]WAY 100635, was used to image central 5-HT(1A) receptors in rat following pretreatment with graded doses of (-)-pindolol (0.001-3 mg/kg, i.v.). The use of PET had advantages over ex vivo radioligand binding met