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Differential Occupancy of Somatodendritic and Postsynaptic 5HT1A Receptors by Pindolol: A Dose-Occupancy Study with [11C]WAY 100635 and Positron Emission Tomography in Humans

โœ Scribed by Diana Martinez; Dah-Ren Hwang; Osama Mawlawi; Mark Slifstein; Justine Kent; Norman Simpson; Ramin V. Parsey; Tomoki Hashimoto; Yiyun Huang; Ann Shinn; Ronald Van Heertum; Anissa Abi-Dargham; Stephen Caltabiano; Andrea Malizia; Hugh Cowley; J.John Mann; Marc Laruelle


Book ID
114280717
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
531 KB
Volume
24
Category
Article
ISSN
1470-634X

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Pindolol occupancy of 5-HT1A receptors m
โœ Ella Hirani; Jolanta Opacka-Juffry; Roger Gunn; Imtiaz Khan; Trevor Sharp; Susan ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 362 KB ๐Ÿ‘ 1 views

Positron emission tomography (PET), following an intravenous injection of [carbonyl-(11)C]WAY 100635, was used to image central 5-HT(1A) receptors in rat following pretreatment with graded doses of (-)-pindolol (0.001-3 mg/kg, i.v.). The use of PET had advantages over ex vivo radioligand binding met