Benzodiazepine receptor occupancy in the brain following oral administration of clonazepam (CZP) with a dose of 30 gg/kg in six healthy young men and a further dose of 50 gg/kg in one of the subjects was estimated by carbon-ll labeled Rol 5-1788 and positron emission tomography (PET). The effects of
Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant
✍ Scribed by Mats Bergström; Richard J Hargreaves; H.Donald Burns; Michael R Goldberg; David Sciberras; Scott A Reines; Kevin J Petty; Mattias Ögren; Gunnar Antoni; Bengt Långström; Olli Eskola; Mika Scheinin; Olof Solin; Anup K Majumdar; Marvin L Constanzer; Wendy P Battisti; Thomas E Bradstreet; Cynthia Gargano; Jarmo Hietala
- Book ID
- 119196364
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 191 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0006-3223
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## Aims We have evaluated the sedative properties of H1-antihistamines by using positron emission tomography (PET) and 11 C-doxepin. The purpose of the present study was to measure histamine H1 receptor occupancy (H1RO) of loratadine 10 mg in patients with allergic rhinitis and to compare this occ