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Positive Selection in Prion Protein

✍ Scribed by Marko Premzl; Vera Gamulin


Publisher
Springer
Year
2009
Tongue
English
Weight
164 KB
Volume
68
Category
Article
ISSN
0022-2844

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## Abstract ## Objective: Transgenic (Tg) mice expressing chimeras of mouse and human prion proteins (PrPs) have shorter incubation periods for Creutzfeldt‐Jakob disease (CJD) prions than mice expressing full‐length human PrP. Increasing the sequence similarity of the chimeric PrP to mouse PrP, by

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