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Copper Binding in the Prion Protein

✍ Scribed by Glenn L. Millhauser


Publisher
John Wiley and Sons
Year
2004
Weight
46 KB
Volume
35
Category
Article
ISSN
0931-7597

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The N-terminal octapeptide repeat region of human prion protein (PrP c ) is known to bind Cu II . To investigate the binding modes of copper in PrP c , an octapeptide Ac-PHGGGWGQ-NH 2 (1), which corresponds to an octarepeat sequence, and a tetrapeptide Ac-HGGG-NH 2 (2) have been synthesised. The cop