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Positive regulation of P15 (INK4B), a tumor suppressor gene, in melanoma cell lines by tetracycline

✍ Scribed by Pacheco, T.R.; Na, S.; Norris, D.A.; Weston, W.; Maxwell, I.H.


Book ID
119562587
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
192 KB
Volume
16
Category
Article
ISSN
0923-1811

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Chromosome 9p21 is frequently deleted in malignant melanoma, and one familial malignant melanoma gene has been linked to 9p21-22. Recently, the cyclin D-dependent kinase inhibitors (CDKIs) p16INK4a and p15INK4b have been localized within chromosome 9p21, and the presence of p16INK4a point mutations