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Tumor suppressor INK4: Refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data

✍ Scribed by Chunhua Yuan; Thomas L. Selby; Junan Li; In-Ja L. Byeon; Ming-Daw Tsai

Book ID
111753802
Publisher
Cold Spring Harbor Laboratory Press
Year
2000
Tongue
English
Weight
941 KB
Volume
9
Category
Article
ISSN
0961-8368

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## Background: It has been suggested that cyclin-dependent kinase inhibitors (cdkis), including p16 and p15, are tumor suppressor genes. alterations of cdkis have been found in most types of cancer. however, little is known about the status of p16 and p15 genes, including methylation of the promote