✦ LIBER ✦

Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia

✍ Scribed by Inayama, Yasuhiro; Yoneda, Hiroshi; Sakai, Toshiaki; Ishida, Toru; Nonomura, Yasuhiro; Kono, Yoshihiro; Takahata, Ryu-ichi; Koh, Jun; Sakai, Jun; Takai, Akiko; Inada, Yasushi; Asaba, Hiroyuki

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 10 KB
Volume: 67
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19960216)67:1<103::aid-ajmg18>3.0.co;2-s

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✦ Synopsis

Sixty-two patients with schizophrenia and 96 normal controls were investigated for genetic association with restriction fragment length polymorphisms (RFLPs) in the serotonin receptor genes. A positive association between the serotonin 2A receptor gene (HTR2A) and schizophrenia was found, but not between schizophrenia and the serotonin 1A receptor gene. The positive association we report here would suggest that the DNA region with susceptibility to schizophrenia lies in the HTRZA on the long arm of chromosome 13. 0 1996 Wiley-Liss, Inc.

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