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Serotonin-2A receptor gene is not associated with symptomatology of schizophrenia

✍ Scribed by Serretti, Alessandro; Cusin, Cristina; Lorenzi, Cristina; Lattuada, Enrico; Lilli, Roberta; Smeraldi, Enrico

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 17 KB
Volume: 96
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(20000207)96:1<84::aid-ajmg17>3.0.co;2-9

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✦ Synopsis

The serotonin receptor type 2A (5-HT2A) is a primary candidate for involvement in major psychoses. Polymorphisms within the 5-HT2A gene have recently been reported to be associated with a variety of psychopathological conditions. In the present study, we investigated the potential influence of the T102C polymorphism on the psychopathology of schizophrenia. One hundred eightyeight inpatients affected by schizophrenia (DSM-III-R) were assessed by the Operational Criteria checklist for psychotic illness (OPCRIT) and were typed for their 5-HT2A variants by PCR techniques. Mania, depression, delusion and disorganization were the four symptomatologic factors previously derived from our psychotic population that were used to define phenotype in our sample. Genetic variants of the polymorphism under study were not associated with these symptomatologic factors, and consideration of possible stratification effects such as sex and age of onset did not reveal any association either. Our results do not, therefore, support the hypothesis that the serotonin receptor 2A gene is a liability factor for the symptomatology of schizophrenia as defined by the OPCRIT checklist.

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