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Poly(ε-L-lysine): Synthesis and conformation

✍ Scribed by D. R. S. Kushwaha; K. B. Mathur; D. Balasubramanian

Publisher
Wiley (John Wiley & Sons)
Year
1980
Tongue
English
Weight
589 KB
Volume
19
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

The synthesis of poly(ε‐L‐lysine) is described. This is a poly(ε‐amino acid) in which the ε‐amino group of lysine is condensed with the α‐carboxyl group to produce a chain backbone that is a variant of the usual one seen in proteins and the side chain is the α‐amino group. Conformational studies of poly(ε‐L‐lysine) and its t‐butyloxycarbonyl derivative suggest the likelihood of a chain order that is formally similar to the antiparallel pleated‐sheet conformation of proteins.

📜 SIMILAR VOLUMES

Synthesis and conformational properties
Synthesis and conformational properties of polypeptides containing long aliphatic side chains. Poly(Nε-stearyl-L-lysine) and poly(Nε-pelargonyl-L-lysine)
✍ Valery Shibaev; Manlio Palumbo; Evaristo Peggion 📂 Article 📅 1975 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 393 KB 👁 1 views

## Abstract Poly(__N__^ε^‐stearyl‐L‐lysine) and poly(__N__^ε^‐pelargonyl‐L‐lysine) were synthesized both by polymerization of __N__^ε^‐pelargonyl and __N__^ε^‐stearyl‐L‐lysine NCA and by acylation of poly(L‐lysine) with pelargonyl and stearyl chloride. This second route has proven to be very useful

Conformational change of poly-Nε-glutary
Conformational change of poly-Nε-glutary-L-lysine and poly-Nε-succinyl-L-lysine in aqueous salt solutions
✍ Norio Murai; Shintaro Sugai 📂 Article 📅 1974 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 464 KB 👁 1 views

## Abstract The conformational changes of poly‐__N__^ε^‐glutaryl‐L‐lysine (PGL) and poly‐__N__^ε^‐succinyl‐L‐lysine (PSL) in various salt solutions were studied by use of ORD and potentiometric titration measurements. The addition of alkali metal salts to the fully ionized PGL or PSL solution cause

Conformation of poly(L-lysine) homologs
Conformation of poly(L-lysine) homologs in solution
✍ Yuen-Wen Tseng; Jen Tsi Yang 📂 Article 📅 1977 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 704 KB

The effect of the number of methylene groups in the side chains on the conformation of polypeptides is assessed for three poly(L-lysine) homologs with R = -(CHz),,NHz. Circular dichroism studies show a pH-induced helix-coil transition in 0.05 M KCl with midpoints a t 9.6, 9.0, and 8.7 for n = 5, 6,