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Polysialic acid and the regulation of cell interactions

✍ Scribed by Urs Rutishauser

Book ID
117647871
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
667 KB
Volume
8
Category
Article
ISSN
0955-0674

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Polysialic acid (PSA) is a long polymer of negatively-charged sialic acid associated with the neural cell adhesion molecule. PSA serves as a potent negative regulator of cell interactions via its unusual biophysical properties. During development the abundant and regulated expression of this carbohy

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## Abstract Expression of polysialic acid (PSA) promotes migration of progenitor cells from the subventricular zone (SVZ) to the olfactory bulb, where they differentiate into interneurons. This differentiation has been found to coincide with a loss of PSA. Moreover, specific removal of PSA from the