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Polyoma t-antigen-derived synthetic peptides induce polyoma-virus-specific macrophage migration inhibition

✍ Scribed by Git Reinholdsson; Torbjörn Ramqvist; Robert Sziget; Tina Dalianis

Publisher
John Wiley and Sons
Year
1989
Tongue
French
Weight
428 KB
Volume
43
Category
Article
ISSN
0020-7136

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✦ Synopsis

Synthetic peptides, 2 derived from the sequence common to small, middle and large T-antigen, and I derived from the sequence unique for middle T, activated lymphocytes from polyoma-virus-immunized, but not from control mice, to release the lymphokine migration inhibitory factor (MIF). In contrast, purified, bacterially grown, full-length small Tantigen and a middle T-antigen mutant Py 1387T MT (lacking 37 C-terminal amino acids) did not induce lymphokine release, although they were capable of inducing an antipolyoma TSTA response in vivo.

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