## Abstract Squamous cell carcinoma of the head and neck (SCCHN), which is relatively prevalent in Korea, is believed to be induced by environmental carcinogens and host genetic factors. Accumulating evidence has shown that genetic differences in DNA repair capacity resulting from genetic polymorph
Polymorphisms of the XRCC1 DNA repair gene in head and neck cancer
✍ Scribed by Semra Demokan; Deniz Demir; Yusufhan Suoglu; Erkan Kiyak; Ugur Akar; Nejat Dalay
- Publisher
- Springer Netherlands
- Year
- 2005
- Tongue
- English
- Weight
- 416 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1219-4956
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Cigarette smoke can generate reactive oxygen species, which are capable of inducing double‐strand breaks (DSBs) in DNA. Polymorphisms in __XRCC2__ and __XRCC3__ genes, involved in DSBs repair pathways, may alter an individual's susceptibility to smoking‐related cancers. We investigated
## Abstract ## BACKGROUND. Tobacco smoke contains numerous carcinogens that cause DNA damage, including oxidative lesions that are removed effectively by the base‐excision repair (BER) pathway, in which adenosine diphosphate ribosyl transferase (ADPRT), x‐ray repair cross‐complementing 1 (XRCC1),
Polymorphisms have been identified in several DNA repair genes. These polymorphisms may effect DNA repair capacity and modulate cancer susceptibility. In this study, we aimed to determine the four polymorphisms in two DNA repair genes, xeroderma pigmentosum complementation group D (XPD) and X-ray re