Polymorphisms have been identified in several DNA repair genes. These polymorphisms may effect DNA repair capacity and modulate cancer susceptibility. In this study, we aimed to determine the four polymorphisms in two DNA repair genes, xeroderma pigmentosum complementation group D (XPD) and X-ray re
Genetic polymorphisms of DNA repair gene XRCC1 and risk of uterine leiomyoma
β Scribed by Yang Yang; Xian Dun Zhai; Lin Bo Gao; Shi Liu Li; Zheng Wang; Guo Di Chen
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 316 KB
- Volume
- 338
- Category
- Article
- ISSN
- 0300-8177
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A variety of environmental factors were identified to be associated with the risk of esophageal cancer. The variation in capacity of DNA repair might influence environmental chemical-associated carcinogenesis. We hypothesized that the polymorphic XRCC1 genes might modify cancer susceptibility of the
## Abstract DNA repair variants may play a potentially important role in an individual's susceptibility to developing cancer. Numerous studies have reported the association between genetic single nucleotide polymorphisms (SNPs) in DNA repair genes and different types of hematologic cancers. However