Genetic polymorphisms in cell cycle regu
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Xuemei Zhang; Xiaoping Miao; Yongli Guo; Wen Tan; Yifeng Zhou; Tong Sun; Yonggan
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Article
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2005
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John Wiley and Sons
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English
β 226 KB
The tumor suppressor TP53 pathway plays a crucial role in preventing carcinogenesis through its ability to impose cell cycle arrest and apoptosis following DNA damage and oncogene activation. MDM2 is a key negative regulator of the TP53 pathway and is overexpressed in many cancers as oncoprotein. We