The tumor suppressor TP53 pathway plays a crucial role in preventing carcinogenesis through its ability to impose cell cycle arrest and apoptosis following DNA damage and oncogene activation. MDM2 is a key negative regulator of the TP53 pathway and is overexpressed in many cancers as oncoprotein. We
โฆ LIBER โฆ
Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer
โ Scribed by Sajid A. Khan; Kamran Idrees; Ann Forslund; Zhaoshi Zeng; Shoshana Rosenberg; Hanna Pincas; Francis Barany; Kenneth Offit; Michael P. LaQuaglia; Philip B. Paty
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 120 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
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## Abstract Disease expression in hereditary nonpolyposis colorectal cancer (HNPCC) cannot be readily explained by mutation site in the respective DNA mismatch repair genes associated with this disorder. One explanation is the role of modifying genes that can either promote or prevent disease devel