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Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer

โœ Scribed by Sajid A. Khan; Kamran Idrees; Ann Forslund; Zhaoshi Zeng; Shoshana Rosenberg; Hanna Pincas; Francis Barany; Kenneth Offit; Michael P. LaQuaglia; Philip B. Paty


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
120 KB
Volume
97
Category
Article
ISSN
0022-4790

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## Abstract Disease expression in hereditary nonpolyposis colorectal cancer (HNPCC) cannot be readily explained by mutation site in the respective DNA mismatch repair genes associated with this disorder. One explanation is the role of modifying genes that can either promote or prevent disease devel