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Polymorphisms in the Reduced Folate Carrier, Thymidylate Synthase, or Methionine Synthase and Risk of Colon Cancer

✍ Scribed by Ulrich, C. M.


Book ID
111671417
Publisher
American Association for Cancer Research
Year
2005
Tongue
English
Weight
229 KB
Volume
14
Category
Article
ISSN
1055-9965

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Polyglutamation of methotrexate with com
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## Abstract ## Objective Methotrexate (MTX) enters cells through the reduced folate carrier (RFC‐1) and exerts part of its effects through polyglutamation to MTX polyglutamates (MTXPGs) and inhibition of 5‐aminoimidazole‐4‐carboxamide ribonucleotide transformylase (ATIC) and thymidylate synthase (