Polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and thymidylate synthase (TYMS) in multiple myeloma risk
✍ Scribed by Carmen S.P. Lima; Manoela M. Ortega; Margareth C. Ozelo; Renato C. Araujo; Cármino A. De Souza; Irene Lorand-Metze; Joyce M. Annichino-Bizzacchi; Fernando F. Costa
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 133 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0145-2126
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Folic acid administration to women in the periconceptional period reduces the occurrence of neural tube defects (NTDs) in their offspring. A polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), 677C¨T, is the first genetic risk factor for NTDs in man identified at the molec