Polymorphisms in the p63 and p73 genes are associated with ovarian cancer risk and clinicopathological variables
✍ Scribed by Xiao Guan, Ning Zhang, Yongshuo Yin…
- Book ID
- 120698307
- Publisher
- BioMed Central
- Year
- 2012
- Tongue
- English
- Weight
- 194 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1756-9966
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## Abstract __p73__, a structural and functional homologue of __p53__, shares some p53‐like tumor suppressor activity but also possesses oncogenic activity. Therefore, __p73__ plays an important role in modulating cell‐cycle control and apoptosis. A potentially functional dinucleotide polymorphism,
## Abstract Polymorphisms at loci controlling cellular processes such as cell cycle, DNA repair, and apoptosis may modulate the risk of cancer. We examined the association of two linked polymorphisms (G4C14–A4T14) at __p73__ and one polymorphism (309G > T) at __MDM2__ promoter with the risk of leuk