Polymorphism of CCR5 Affecting HIV Disease Progression in the Japanese Population
β Scribed by Kageyama, Seiji; Mimaya, Jun-Ichi; Yamada, Kaneo; Kurimura, Takashi; Shiraki, Kimiyasu
- Book ID
- 120253057
- Publisher
- Mary Ann Liebert
- Year
- 2001
- Tongue
- English
- Weight
- 114 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0889-2229
No coin nor oath required. For personal study only.
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## Abstract Homozygous (Ξccr5/Ξccr5) and heterozygous (CCR5/Ξccr5) deletions in the Ξ²βchemokine receptor 5 (CCR5) gene, which encodes for the major coβreceptor for macrophageβtropic HIVβ1 entry, have been implicated in resistance to HIV infection and in protection against disease progression, respe
## Abstract HIV positive individuals heterozygous for a 32 basepair deletion in the CCR5 encoding gene (CCR5 Ξ32) have a reduced number of CCR5 receptors on the cell surface and a slower progression towards AIDS and death. Other human polymorphisms, such as the CCR2 64I and the CCR5 promoter β2459