The role of a mutant CCR5 allele in HIV–1 transmission and disease progression
✍ Scribed by Huang, Yaoxing; Paxton, William A.; Wolinsky, Steven M.; Neumann, Avidan U.; Zhang, Linqi; He, Tian; Kang, Stanley; Ceradini, Daniel; Jin, Zhanqun; Yazdanbakhsh, Karina
- Book ID
- 109932193
- Publisher
- Nature Publishing Group
- Year
- 1996
- Tongue
- English
- Weight
- 400 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1078-8956
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A possible correlation between the rate of vertical transmission of HIV-1 and the presence of the defective HIV co-receptor gene ⌬32ccr5 in the chromosomes of infants born to HIV-positive mothers was assessed. The prevalence and genotypic distribution of the ⌬32ccr5 gene were studied in 451 uninfect
## Abstract HIV positive individuals heterozygous for a 32 basepair deletion in the CCR5 encoding gene (CCR5 Δ32) have a reduced number of CCR5 receptors on the cell surface and a slower progression towards AIDS and death. Other human polymorphisms, such as the CCR2 64I and the CCR5 promoter −2459