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The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression

โœ Scribed by Michael, Nelson L.; Chang, George; Loum, Leslie G.; Mascola, John R.; Dondero, Dale; Birx, Deborah L.; Sheppard, Haynes W.


Book ID
109927706
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
343 KB
Volume
3
Category
Article
ISSN
1078-8956

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## Abstract Homozygous (ฮ”ccr5/ฮ”ccr5) and heterozygous (CCR5/ฮ”ccr5) deletions in the ฮฒโ€chemokine receptor 5 (CCR5) gene, which encodes for the major coโ€receptor for macrophageโ€tropic HIVโ€1 entry, have been implicated in resistance to HIV infection and in protection against disease progression, respe