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CCR5 promoter polymorphism and HIV-1 disease progression

โœ Scribed by David H McDermott; Peter A Zimmerman; Florence Guignard; Cynthia A Kleeberger; Susan F Leitman; Philip M Murphy

Book ID
117311297
Publisher
The Lancet
Year
1998
Tongue
English
Weight
136 KB
Volume
352
Category
Article
ISSN
0140-6736

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## Abstract HIV positive individuals heterozygous for a 32 basepair deletion in the CCR5 encoding gene (CCR5 ฮ”32) have a reduced number of CCR5 receptors on the cell surface and a slower progression towards AIDS and death. Other human polymorphisms, such as the CCR2 64I and the CCR5 promoter โˆ’2459