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Polymorphism at codon 72 of the p53 gene in human acute myelogenous leukemia

โœ Scribed by Zhang, Wei; Hu, Guiying; Deisseroth, Albert


Book ID
122789907
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
469 KB
Volume
117
Category
Article
ISSN
0378-1119

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A single nucleotide polymorphism (SNP) in the promoter of MDM2 gene, SNP309 T>G (a T-G exchange at nucleotide 309 in the first intron), can increase the expression level of MDM2, thereby causing an impairment of p53 tumor suppressor activity. A G-C exchange at p53 codon 72 polymorphism results in a