๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

High order interactions of xenobiotic metabolizing genes and P53 codon 72 polymorphisms in acute leukemia

โœ Scribed by Pradeep Singh Chauhan; Rakhshan Ihsan; Ashwani Kumar Mishra; Dhirendra Singh Yadav; Sumita Saluja; Vishakha Mittal; Sunita Saxena; Sujala Kapur

Book ID
115555717
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
222 KB
Volume
53
Category
Article
ISSN
0893-6692

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Polymorphisms of xenobiotic metabolizing
Polymorphisms of xenobiotic metabolizing enzymes and DNA repair genes and outcome in childhood acute lymphoblastic leukemia
โœ Vanessa da Silva Silveira; Renata Canalle; Carlos Alberto Scrideli; Rosane Gomes ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 198 KB

The interindividual variation in the activity of xenobiotic metabolizing enzymes and DNA repair genes could modify an individual's risk of recurrent malignancy and response to therapy. We investigated whether ALL outcome was related to polymorphisms in genes CYP2D6, MPO, EPHX1, NQO1, TS, XPD and XRC

Risk of MDM2 SNP309 alone or in combinat
Risk of MDM2 SNP309 alone or in combination with the p53 codon 72 polymorphism in acute myeloid leukemia
โœ Xiujuan Xiong; Min Wang; Lin Wang; Jiazhuo Liu; Xin Zhao; Zheng Tian; Jianxiang ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 160 KB

A single nucleotide polymorphism (SNP) in the promoter of MDM2 gene, SNP309 T>G (a T-G exchange at nucleotide 309 in the first intron), can increase the expression level of MDM2, thereby causing an impairment of p53 tumor suppressor activity. A G-C exchange at p53 codon 72 polymorphism results in a