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Polymorphic tandem repeat sequences of the thymidylate synthase gene correlates with cellular-based sensitivity to fluoropyrimidine antitumor agents

✍ Scribed by Ayako Yawata; Su-Ryang Kim; Atsuko Miyajima; Takashi Kubo; Seiichi Ishida; Yoshiro Saito; Yukiko Nakajima; Noriko Katori; Yoshiaki Matsumoto; Masamichi Fukuoka; Yasuo Ohno; Shogo Ozawa; Jun-ichi Sawada

Book ID
105992333
Publisher
Springer
Year
2005
Tongue
English
Weight
300 KB
Volume
56
Category
Article
ISSN
0344-5704

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## Abstract Thymidylate synthase (TS) is the primary target of 5‐fluorouracil (5‐FU). A VNTR polymorphism in the TS promoter region is associated with the efficacy of 5‐FU‐based chemotherapy in colorectal cancer. A common G>C SNP at the 12th nucleotide of the second repeat in the TS\*3 alleles has