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📜 SIMILAR VOLUMES
Nuclear DNA has been analyzed by means of restriction endonuclease mapping procedure to identify chromosomes that carry mutant Hb Köln beta-globin genes in a family with individuals heterozygous for this disease. Inherited DNA polymorphisms within the beta-globin gene cluster yielded a direct linkag
Mapping of the DNA from 14 Mediterranean subjects indicates a genetic variation in an Hinf I recognition site located 1 kilobase 5' to the beta-globin gene. This Hinf I site was found associated with eight beta-thalassemic genes and 11 normal beta genes, and hence is not specifically linked to beta-
## Abstract We report on three novel polymorphisms in and around the β globin gene. Two of them are intronic (IVS2) polymorphisms (IVS 2 nt 200–203 (−CTTT) and IVS2 82–83 (−AG)). The third is a novel G→C substitution at nt +1707 related to the β globin cap site. This +1707 G→C polymorphism was dete