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Polymorphic metabolism by functional alterations of human cytochrome P450 enzymes

โœ Scribed by Im-Soon Lee; Donghak Kim

Book ID
107642575
Publisher
Springer
Year
2011
Tongue
English
Weight
320 KB
Volume
34
Category
Article
ISSN
0253-6269

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โœ Seetal Dodd; David W. Boulton; Graham D. Burrows; C. Lindsay De Vane; Trevor R. ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 52 KB ๐Ÿ‘ 1 views

The metabolism of mirtazapine enantiomers was investigated in vitro using human lymphoblast microsomes transfected with human cDNA to overexpress either CYP1A2, CYP2C9, CYP2C19, CYP2D6 or CYP3A4 and assayed for mirtazapine enantiomers using a validated chiral method of high-performance liquid chroma