𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Polymorphic loci of E2F2, CCND1 and CCND3 are associated with HER2 status of breast tumors

✍ Scribed by Christina Justenhoven; Christiane B. Pierl; Susanne Haas; Hans-Peter Fischer; Ute Hamann; Christian Baisch; Volker Harth; Anne Spickenheuer; Sylvia Rabstein; Caren Vollmert; Thomas Illig; Beate Pesch; Thomas Brüning; Jürgen Dippon; Yon-Dschun Ko; Hiltrud Brauch

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
91 KB
Volume
124
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Overexpression of the human epidermal growth factor receptor 2 (HER2) in breast tumors is associated with bad prognosis. Therefore, it is highly relevant to further improve understanding of the regulatory mechanisms of HER2 expression. In addition to gene amplification, transcriptional regulation plays a crucial role in HER2 overexpression. In this study, we analyzed 3 polymorphisms E2F2_‐5368_A>G, CCND1_870_A>G and CCND3_‐677_C>T located in genes involved in cell cycle regulation in the GENICA population‐based and age‐matched breast cancer case‐control study from Germany. We genotyped 1,021 cases and 1,015 controls by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS). Statistical analyses were performed by conditional logistic regression. We observed no differences in genotype frequencies between breast cancer cases and controls. Subgroup analysis showed associations between carriers of the E2F2_‐5368_G allele (OR: 0.60, 95% CI: 0.42–0.85), carriers of the CCND1_870_G allele (OR: 0.66, 95% CI: 0.45–0.96) and carriers of the CCND3_‐677_T allele (OR: 1.72, 95% CI: 1.20–2.49) and HER2 expression in breast tumors. This finding points to an association of an increased expression of these cell cycle regulators with lower expression of HER2. An explanation for this observation might be that low expression of E2F2, CCND1 and CCND3 decrease levels of factors down‐regulating HER2. We conclude that the analyzed polymorphisms located in E2F2, CCND1 and CCND3 are potential markers for HER2 status of breast tumors. © 2008 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

HER-2/neu status and tumor morphology of
HER-2/neu status and tumor morphology of invasive breast carcinomas in Ashkenazi women with known BRCA1 mutation status in the Ontario Familial Breast Cancer Registry
✍ Louise A. Quenneville; Kelly-Anne Phillips; Hilmi Ozcelik; Robert K. Parkes; Jul 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 83 KB 👁 2 views

## Abstract ## BACKGROUND The prevalence of BRCA1 germline mutations is greater in the Ashkenazi Jewish population than in the general North American population. The Ontario Familial Breast Cancer Registry collects clinical and family history data in familial breast carcinoma cases, and unselected

CYP1A1 CYP2E1 and GSTM1 polymorphisms ar
CYP1A1 CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus
✍ Shunji Morita; Masahiko Yano; Hitoshi Shiozaki; Toshimasa Tsujinaka; Chikara Ebi 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 43 KB 👁 1 views

We investigated the genetic polymorphisms of CYP1A1, CYP2E1 and GSTM1 in Japanese esophageal cancer patients (n = 53) with a histological diagnosis of squamous-cell carcinoma, to determine whether susceptibility to esophageal cancer is associated with these polymorphisms. There were no significant d

Genetic polymorphisms of CYP2D6*10 and C
Genetic polymorphisms of CYP2D6*10 and CYP2C19*2, *3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen
✍ Matthew Goetz; Vera Suman 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 56 KB 👁 1 views

The study by Okishiro et al 1 concludes that the cytochrome P450 (CYP) genotype CYP2D6\*10/\*10 is unlikely to have a clinically significant impact on prognosis in women with breast cancer who receive adjuvant tamoxifen. However, several aspects of the study by Okishiro et al call their conclusions

Chromatin reorganization accompanying ce
Chromatin reorganization accompanying cellular dedifferentiation is associated with modifications of histone H3, redistribution of HP1, and activation of E2F-target genes
✍ Leor Williams; Jing Zhao; Nadya Morozova; Yan Li; Yigal Avivi; Gideon Grafi 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 397 KB

## Abstract The remarkable regeneration capacity of plant cells is based on their capability to dedifferentiate. We recently reported that cellular dedifferentiation proceeds through two distinct phases, each accompanied by chromatin decondensation: acquisition of competence for fate switch followe