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Genetic polymorphisms of CYP2D610 and CYP2C192,*3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen

✍ Scribed by Masatsugu Okishiro; Tetsuya Taguchi; Seung Jin Kim; Kenzo Shimazu; Yasuhiro Tamaki; Shinzaburo Noguchi

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 469 KB
Volume: 115
Category: Article
ISSN: 0008-543X
DOI: 10.1002/cncr.24111

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The study by Okishiro et al 1 concludes that the cytochrome P450 (CYP) genotype CYP2D6\*10/\*10 is unlikely to have a clinically significant impact on prognosis in women with breast cancer who receive adjuvant tamoxifen. However, several aspects of the study by Okishiro et al call their conclusions

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Reply to Genetic polymorphisms of CYP2D6*10 and CYP2C19*2,*3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen

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