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Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment

โœ Scribed by Magnus Ingelman-Sundberg; Mikael Oscarson; Roman A McLellan

Book ID
117341900
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
639 KB
Volume
20
Category
Article
ISSN
0165-6147

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We previously clarified that major human drug metabolizing enzymes were expressed in a chimeric urokinase-type plasminogen activator (uPA)+/+/severe combined immunodeficient (SCID) mouse line established recently, in which the liver could be replaced by more than 80% with human hepatocytes. In the p