Polymer-supported triacetoxyborohydride: a novel reagent of choice for reductive amination
β Scribed by Sukanta Bhattacharyya; Sunil Rana; Owen W Gooding; Jeff Labadie
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 180 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A novel polymer-supported triacetoxyborohydride reagent for reductive amination of aldehydes and ketones is reported. The bound reagent was found to be shelf-stable and provided broad scope and reactivity in reductive amination reactions under mild reaction conditions. Streamlined protocols for its application in reductive amination reactions using both primary and secondary amines are described.
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
A commercially available and inexpensive compound, 3-amino-1,2,4-dithiazole-5-thione (ADTT), has been attached onto a hydroxyl resin via a succinic acid linker. The polymer-supported ADTT is an efficient sulfur-transfer reagent for the solution-phase synthesis of phosphorothioates.
New reagents for the high yielding amidination of primary and secondary amines are described. By attaching a benzyl substituent to the 3,5-dimethyl-1H-pyrazole-1-carboxamidine ring, a reagent 1 is obtained which allows easy work-up after amidination because of solubility of byproducts in organic sol