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A new reagent and its polymer-supported variant for the amidination of amines

✍ Scribed by Gerald Dräger; Wladimir Solodenko; Josef Messinger; Uwe Schön; Andreas Kirschning

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
120 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

New reagents for the high yielding amidination of primary and secondary amines are described. By attaching a benzyl substituent to the 3,5-dimethyl-1H-pyrazole-1-carboxamidine ring, a reagent 1 is obtained which allows easy work-up after amidination because of solubility of byproducts in organic solvents. In addition, the polystyrene-bound analogue 2 was prepared which allows amidination of various amines with high purity.

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