A new polymer-supported reagent for the Fmoc-protection of amino acids
✍ Scribed by Rafael Chinchilla; David J Dodsworth; Carmen Nájera; José M Soriano
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 58 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A new polymer-supported Fmoc-OSu (Fmoc-P-OSu) has been prepared from polymer-bound N-hydroxysuccinimide (P-HOSu), and used as a solid-supported reagent for the Fmoc-protection of amino groups. The residual P-HOSu generated after the protection reaction can be separated by simple filtration and reused.
📜 SIMILAR VOLUMES
Esterification of Fmoc {fluo~e~-9-y~methyloxy~~bonyl) amino acid ot amino acid derivative to 4-~~ox~benzy~~cohol resin was achieved in generally good yield using a new esterScation reagent, CIP [2-~hloro~~,3-dim~th~~~m~~zo~~dini~m hexafluoro-phosphate1 or BOI [2-(benzotriazol-l-y!) oxy-1,3-dimethyli
New reagents for the high yielding amidination of primary and secondary amines are described. By attaching a benzyl substituent to the 3,5-dimethyl-1H-pyrazole-1-carboxamidine ring, a reagent 1 is obtained which allows easy work-up after amidination because of solubility of byproducts in organic sol