✦ LIBER ✦

Anchoring of Fmoc amino acid to 4-alkoxybenzyl alcohol resin using a new esterification reagent

✍ Scribed by Kenichi Akaji; Naohiro Kuriyama; Tooru Kimura; Yoichi Fujiwara; Yoshiaki Kiso

Publisher: Elsevier Science
Year: 1992
Tongue: French
Weight: 359 KB
Volume: 33
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)79845-5

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✦ Synopsis

Esterification of Fmoc {fluo~e~-9-y~methyloxy~~bonyl) amino acid ot amino acid derivative to 4-~~ox~benzy~~cohol resin was achieved in generally good yield using a new esterScation reagent, CIP [2-~hloro~~,3-dim~th~~~m~~zo~~dini~m hexafluoro-phosphate1 or BOI [2-(benzotriazol-l-y!) oxy-1,3-dimethylimidazolidinium hexafluorophosphat.e]. The reaction was rapider with the same or Iowa racemization level than the anchoring reaction using the conventional esterification reagents.

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