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Polystyrylsulfonyl-3-nitro-1H-1,2,4-triazolide-resin: a new solid-supported reagent for the esterification of amino acids

✍ Scribed by Norbert Zander; Jürgen Gerhardt; Ronald Frank

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 78 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)01698-8

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✦ Synopsis

We describe the application of the polystyrylsulfonyl-3-nitro-1H-1,2,4-triazolide-resin, readily available from the corresponding commercially available polystyryl sulfonyl chloride resin, to the solution-phase synthesis of esters from protected a-amino acids and alcohols in high yields and purity with a low level of racemisation of the amino acids. All by-products can be removed by filtration and extraction.

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