Polymer Supported Synthesis of Disubstituted N-Cyano-Guanidines
✍ Scribed by Zupan, M.; Ŝket, B.; Vodopivec, J.; Zupet, P.; Molan, S.; Japelj, M.
- Book ID
- 120053006
- Publisher
- Taylor and Francis Group
- Year
- 1981
- Tongue
- English
- Weight
- 344 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0039-7911
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A method for the solid-phase synthesis of disubstituted guanidines is reported. In this procedure, polymer-bound aryl or alkyl amines are converted to methyl isothioureas in three steps and treated with primary and secondary amines to form the disubstituted guanidine products.
A novel methodology for the synthesis of guanidines from amines has been developed using polymer assisted synthesis, potentially allowing the preparation of series of compounds in a high throughput manner. The methodology comprises the use of polymer-supported carbodiimide as the activating agent fo