The clean and efficient cleavage of N-benzyl linked tertiary amines from a solid support (e.g. 4) by treatment with ct-chloroethyl chloroformate (ACE-CI) / methanol to yield secondary amines 7 is described. This allows the solid-phase synthetic transformation of the secondary amine 2 into 7. When th
Polymer bound iminodicarbonate: a new ammonia equivalent for solid-phase synthesis of primary amines
โ Scribed by Chakrapani Subramanyam
- Book ID
- 104210686
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 159 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
A polymer bound iminodicarbonate has been designed and its use in solid-phase synthesis of primary amines is reported.
๐ SIMILAR VOLUMES
A novel linker for the solid-phase synthesis of secondary amines based on an intramolecular cyclization was developed. The linker allows for a stepwise built-up of the secondary amines on the support. The feasibility was demonstrated in the parallel synthesis of a small set of different secondary am
A new reagent --4-nitro-l-H-pyrazole-l-[N, N'-bis(ten-butoxycarbonyl)]cmboxamidine --has been develolxd to effect the rapid a~l efficient synthesis of I~(~)-pmtected guanidin~ from and secendm3, amines. The reagent is a more eleclrophilic, sad comfy more derivative of the literature reagent l-H-pyra