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Polyhydroxylated pyrrolidine and 2-oxapyrrolizidine as glycosidase inhibitors

✍ Scribed by Wang, Jen-Tsung; Lin, Ting-Chien; Chen, Ying-Hsuan; Lin, Chun-Hung; Fang, Jim-Min

Book ID
120059303
Publisher
The Royal Society of Chemistry
Year
2013
Tongue
English
Weight
449 KB
Volume
4
Category
Article
ISSN
2040-2503

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## Abstract Two pyrrolidine‐based imino sugars have been synthesized in an efficient manner, using regiospecific amination, ring closing metathesis, and diastereospecific dihydroxylations as key steps. These azasugars are found to be moderate inhibitors of glycosidases. (Β© Wiley‐VCH Verlag GmbH & C