Polyhydroxylated phenylacrylic acid derivatives as new anti-tumor agents
β Scribed by Sajjat Hussoin; George B. Fitzgerald; Michael M. Wick
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 410 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract 2βAminopyridine, sesamol and 4βhydroxyβ3,5βdimethoxybenzaldehyde condense to form a Mannicb base 3b which reacts with tetronic acid to yield lactone 4c. Cyclization of 4c yields the benzopyran lactone 1b; this inhibits growth of tumors in NCI __in vitro__ tests. Alkaline hydrolysis of a
## Abstract magnified image We herein report conventional and microwaveβassisted methods for the synthesis of a series of compounds containing some bivalent ion chelating requirements useful to exert potential HIVβ1 integrase (IN) enzyme inhibition activity. The biological screening highlighted tha