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Synthesis of new pyridazine derivatives as potential anti-HIV-1 agents

✍ Scribed by Stefania Ferro; Stefano Agnello; Maria Letizia Barreca; Laura De Luca; Frauke Christ; Rosaria Gitto

Publisher: Journal of Heterocyclic Chemistry
Year: 2009
Tongue: English
Weight: 86 KB
Volume: 46
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.230

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✦ Synopsis

Abstract

magnified image We herein report conventional and microwave‐assisted methods for the synthesis of a series of compounds containing some bivalent ion chelating requirements useful to exert potential HIV‐1 integrase (IN) enzyme inhibition activity. The biological screening highlighted that only derivative 5 proved to be a strand‐transfer step inhibitor of the virus integration process at micromolar concentration. J. Heterocyclic Chem., (2009).

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