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ChemInform Abstract: New Anti-Tumor Agents. Part 3. Phenolic Benzopyran Lactone and Amine Derivatives.

✍ Scribed by L. JURD


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
28
Category
Article
ISSN
0931-7597

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New anti-tumor agents. 3. Phenolic benzo
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## Abstract 2‐Aminopyridine, sesamol and 4‐hydroxy‐3,5‐dimethoxybenzaldehyde condense to form a Mannicb base 3b which reacts with tetronic acid to yield lactone 4c. Cyclization of 4c yields the benzopyran lactone 1b; this inhibits growth of tumors in NCI __in vitro__ tests. Alkaline hydrolysis of a