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Polyethylenimine with acid-labile linkages as a biodegradable gene carrier

โœ Scribed by Young Heui Kim; Jeong Hyun Park; Minhyung Lee; Yong-Hee Kim; Tae Gwan Park; Sung Wan Kim

Book ID
113690787
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
265 KB
Volume
103
Category
Article
ISSN
0168-3659

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## Abstract ## Background Polyethylenimine (PEI) vectors are widely used in gene delivery because of their high transfection efficiency owing to a unique proton sponge effect. An increase in molecular weight increases transfection efficiency, but simultaneously results in increased toxicity. There